Woofgenix Research Programs

Leading the way in canine longevity science

When you join Woofgenix, your dog isn’t just receiving concierge care — they’re also contributing to our active research studies. Dogs in the membership are automatically enrolled in relevant studies based on their protocol (bloodwork, WoofSpan™, supplements, Rapamycin, etc.). We also selectively recruit additional dogs (by age, breed, or health status) — often with free study participation— to deepen and diversify the data.
Schedule a call with our research team
Our team publishes in the world's top journals

Explore our latest research initiatives

WAGS

Woofgenix Aging and Genomics Study

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BARK

Blood Aging Research in K9s

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CLEAR

Canine Longevity Epigenetics Assessment with Rapamycin

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The WAGS study focus

Biological age, epigenetics, genomics & aging trajectories.

Overview

WAGS is our flagship study exploring how dogs age at the molecular level using WoofSpan™, the first and only canine biological age test. We track DNA methylation and genomic aging signatures across different breeds, ages, and lifestyles.

What we study

  • Biological age vs chronological age
  • Rate of epigenetic aging and “age acceleration”
  • How nutrition, environment, activity, and supplements shift aging curves
  • Genomic and epigenetic patterns in long-lived vs high-risk dogs

Lyme / Tick-Borne Substudy

Within WAGS, we run a focused substudy on Lyme disease and tick-borne illness, investigating:

  • How these infections alter the epigenome
  • Whether epigenetic signatures can serve as a point-of-care tool for detection, severity, and recovery
  • How treatment and time affect biological age in affected dogs

Dogs with a history (confirmed or suspected) of tick-borne disease may be eligible for free WoofSpan™ and follow-up testing under this substudy.

Who’s included

Members: Any dog receiving WoofSpan™ epigenetic testing through the membership.

Recruited dogs (often free):

  • Older dogs (e.g., 8+ years)
  • Rare or underrepresented breeds
  • Dogs with known or suspected tick-borne disease
  • Young, healthy dogs as baseline controls
Apply for WAGS

Interested in WAGS or the Lyme substudy? Schedule a call with our research team to see if your dog qualifies.

The BARK study focus

Blood biomarkers, organ health, metabolism, immune & inflammatory aging

Overview

BARK is our large-scale effort to map how blood biomarkers change with age and how they predict future health and longevity. Using the blood panels from Woofgenix membership and select recruits, we’re building a functional map of canine aging in blood.

What we study

  • Liver, kidney, and pancreatic function over time
  • Cardiometabolic health (glucose, lipids, weight trends)
  • Immune system changes (WBC/RBC patterns)
  • Inflammation, oxidative stress, and “wear-and-tear” markers
  • How diet, supplements, and protocols (including Rapamycin) impact labs

Who’s included

Members: Any dog receiving blood testing through the Woofgenix concierge program

Recruited dogs (often free):

  • Dogs with early or mild organ changes (kidney, liver, etc.)
  • Dogs with chronic inflammatory/immune conditions
  • Giant and large breeds with shorter typical lifespans
  • Seniors transitioning onto new nutrition or supplement protocols

How it fits the membership

Every blood panel run through Woofgenix feeds into BARK and WoofHub™, so your dog’s routine testing becomes part of a much bigger picture of canine aging.

Apply for BARK

Help advance BARK and redefine ‘normal’ canine bloodwork. Schedule a research enrollment call.

The CLEAR study focus

Rapamycin + interventions, epigenetics, biological age & healthspan outcomes

Overview

CLEAR is our interventional research study evaluating how Rapamycin and other longevity strategies influence biological age, epigenetic patterns, and functional outcomes in real dogs.

What we study

  • Changes in WoofSpan™ biological age with Rapamycin and other therapies
  • How supplements and nutrition plans interact with Rapamycin
  • Safety, tolerability, and optimal dosing patterns in the real world
  • Effects on metabolism, inflammation, organ health, and mobility
  • Owner-reported changes in energy, behavior, sleep, comfort, and quality of life (logged monthly via WoofHub™)

Who’s included

Members: Dogs who are clinically approved for Rapamycin protocols and/or advanced longevity interventions

Recruited dogs (often free or subsidized):

  • Senior dogs beginning Rapamycin under supervision
  • Dogs with early aging signs (slowing down, stiffness, early lab changes)
  • Select middle-aged dogs for long-term follow-up cohorts

How it fits the membership

CLEAR runs inside the Woofgenix care model — your dog’s Rapamycin protocol, blood tests, WoofSpan™ results, and monthly surveys all feed into the study automatically.

Apply for CLEAR

Want your dog to be part of the CLEAR Rapamycin research? Schedule a call with our longevity research team.

Help dogs everywhere live healthier, longer.

Membership dogs are automatically enrolled in relevant studies. Select dogs (by age, breed, or health condition) may receive free or subsidized testing when they help fill critical research gaps. Special focus areas include senior dogs, rare breeds, chronic conditions, and tick-borne disease.
Schedule a call with our research team